Posters (PDD, PMS, PNM, PPAT, POT)
نویسندگان
- E. Liedl
- A. Beyer
- P. Wolschann
- H. Viernstein
- A. Steinbach
- R. Süss
- P. Brožič
- S. Gobec
- T. Lanišnik Rižner
- E. Ablinger
- S. Wegscheider
- T. Pavkov-Keller
- W. Keller
- R. Prassl
- A. Zimmer
- J. Wiesbauer
- S. Leitgeb
- B. Nidetzky
- A. Chemelli
- O. Glatter
- S. Milak
- J. Pardeike
- A. Chemelli
- O. Glatter
- A. Zimmer
- É. Petró
- I. Csóka
- Á. Balogh
- G. Blazsó
- I. Erős
- M. Budai-Szűcs
- I. Erős
- P. Herdová
- Z. Vitková
- L. Malaj
- V. Martena
- S. Giovenali
- P. Di Martino
- B. Čalija
- N. Cekić
- S. Savić
- J. Milić
- B. Govedarica
- K. Teskač
- S. Pajk
- S. Pečar
- S. Srčič
- J. Kristl
- M. Homar
- J. Kerč
- A. Zvonar
- M. Gosenca
- M. Gašperlin
- M. Sznitowska
- M. Placzek
- A. Kluk
- D. Péter
- P. Sipos
- P. Kása
- K. Hódi
- B. Pilipović
- M. Vehabović
- E. Hadžović
- N. Šarić
- A. Czajkowska-Kośnik
- M. Sznitowska
- A. Spasić
- I. Homšek
- U. Klančar
- I. Legen
- M. Horvat
- M. Bogataj
- B. Ružić
- B. Perissutti
- D. Voinovich
- A. Mrhar
- J. Božić
- M. Đokić
- B. Bürmen
- I. Locatelli
- A. Mrhar
- M. Bogataj
- S. Schrank
- J. Khinast
- A. Zimmer
- E. Roblegg
- D. Voinovich
- F. Serdoz
- B. Perissutti
- D. Hasa
- J. Pinto
- G. P. Zara
- A. Bargoni
- I. Grabnar
- A. A. Barba
- G. Lamberti
- L. Rabbia
- M. Grassi
- G. Grassi
- D. Larobina
- M. Kerec Kos
- G. Pabst
- H. Jerabek
- M. Rappolt
- T. Stockner
- J. Pradal
- O. Jordan
- C. Gabay
- P. A. Guerne
- M. C. Bagley
- E. Doelker
- J. M. Waldburger
- E. Allémann
- I. Jaksic
- M. Lukic
- R. Daniels
- S. Reichel
- J. Milic
- S. Savic
- T. Ervasti
- J. Ketolainen
- J. Aaltonen
- S. Karner
- N. A. Urbanetz
- A. Elezović
- S. Hadžović
- Š. Hadžidedić
- S. Kostić
- G. Lamberti
- I. Galdi
- G. Titomanlio
- A. A. Barba
- M. d’Amore
- D. Antonyová
- M. Žabka
- J. Oremusová
- J. Oremusová
- Z. Vitková
- P. Herdová
- H. Gruber-Wölfler
- P. Radaschitz
- P. Feenstra
- G. J. Lichtenegger
- E. Polo
- J. G. Khinast
- B. Gutmann
- J. P. Roduit
- D. Roberge
- C. O. Kappe
- D. Obermayer
- T. N. Glasnov
- T. Razzaq
- M. Irfan
- M. Damm
- C. O. Kappe
- M. Irfan
- T. N. Glasnov
- C. O. Kappe
- B. Armstrong
- J. Seville
- D. Parker
- M. S. Siraj
- S. Radl
- J. G. Khinast
- N. Balak
- O. Scheibelhofer
- D. M. Koller
- J. G. Khinast
- S. D. Fraser
- T. Freeman
- T. Hörmann
- M. Gsöll
- J. Hofer
- D. Suzzi
- A. Korbely
- K. Pintye-Hódi
- I. Mašić
- A. Stojković
- J. Parojčić
- Z. Đurić
- C. Muehlenfeld
- R. Steiner
- M. Thommes
- M. Koester
- M. Thommes
- M. Luštrik
- R. Dreu
- S. Srčič
- G. Regdon
- K. Nikowitz
- K. Pintye-Hódi
- U. J. Griesser
- R. Sungkorn
- J. J. Derksen
- J. G. Khinast
- C. Radeke
- S. Radl
- R. Sungkorn
- D. Suzzi
- J. G. Khinast
- R. Šibanc
- R. Dreu
- A. Stojkovic
- I. Masic
- J. Parojcic
- Z. Djuric
- G. Calogerá
- N. Passerini
- B. Albertini
- I. Ilić
- P. Kása
- R. Dreu
- K. Pintye-Hódi
- S. Srčič
- J. A. Kimber
- S. G. Kazarian
- F. Štěpánek
- C. Philippe
- D. Haeusler
- L.-K. Mien
- K. Kletter
- R. Dudczak
- W. Wadsak
- H. Viernstein
- M. Mitterhauser
- É. Bölcskei
- K. Süvegh
- T. Marek
- K. Pintye-hódi
- S. Stummer
- M. C Rabenreither
- H. Viernstein
- M. Wirth
- S. Toegel
- S. Salar-behzadi
- E. E. Kis
- G. Winter
- J. Myschik
- S. Reven
- J. Grdadolnik
- J. Kristl
- E. Žagar
- M. Jović
- M. Jezdić
- J. Petrović
- S. Ibrić
- N. Radoman
- M. Radivojša
- J. petrović
- B. Kovačič
- O. Planinšek
- F. Vrečer
- A. Tomljenović Gluhak
- I. Simčić
- G. Matijašević
- T. Gothsch
- S. Beinert
- J. H. Finke
- C. Lesche
- S. Büttgenbach
- C. Müller-Goymann
- A. Kwade
- F. Wiesbrock
- A. Hecke
- B. Wirnsberger
- A. M. Kelly
- F. Stelzer
- A. Barua
- W. Eagles
- G. Giorgio
- F. Ricard
- F. Stepanek
- S. Kostić
- G. Toschkoff
- D. Suzzi
- F. Reiter
- W. Tritthart
- M. Schlingmann
- J. G. Khinast
- R. J. P. Eder
- E. Schmitt
- J. Grill
- M. Maier
- S. Innerhofer
- H. Gruber-Wölfler
- L. L. Simon
- K. Abbou oucherif
- Z. K. Nagy
- K. Hungerbuhler
- Z. Sáska
- J. Dredán
- E. Balogh
- O. Luhn
- I. Antal
- C. Kussmann
- P. Drage
- D. Kirschneck
- K. Kovács
- N. Kállai
- G. Stampf
- I. Klebovich
- K. Ludányi
- O. Luhn
- I. Antal
- A. Dalmoro
- M. d'Amore
- I. Arsić
- V. Tadić
- D. Runjaić-Antić
- S. Đorđević
- I. Homšek
- E. M. Littringer
- A. Mescher
- H. Schröttner
- P. Walzel
- N. A. Urbanetz
- G. Först
- R. Schubert
- S. Striepe
- J. Rössler
- R. Süss
- E. E. J. Marxer
- J. Brüßler
- A. Becker
- C. Nimsky
- U. Bakowsky
- A. Hafner
- M. Dürrigl
- J. Filipović-Grčić
- G. Almer
- K. Wernig
- M. Saba-Lepek
- S. Haj-Yahya
- J. Kellner
- J. Rattenberger
- A. Gries
- A. Zimmer
- H. Mangge
- S. Blass
- B. Teubl
- E. Fröhlich
- C. Meindl
- D. F. Rabensteiner
- G. Trummer
- O. Schmut
- A. Zimmer
- E. Roblegg
- P. A. Grabnar
- J. Kerč
- M. Homar
- J. Kristl
- S. T. Vučen
- G. Vuleta
- N. Ignjatović
- D. Uskoković
- A. Kovacevic
- S. Savic
- J. Milic
- R. H. Müller
- C. M. Keck
- T. Andreani
- A. L. R. Souza
- A. M. Silva
- C. L. Martins
- E. B. Souto
- J. Pardeike
- S. Weber
- H. P. Zarfl
- A. Zimmer
- S. Schnepfleitner
- N. A. Urbanetz
- D. Reischl
- E. Jantscher-Krenn
- E. Bernhart
- W. Sattler
- A. Zimmer
- C. Petschacher
- A. Eitzlmayr
- S. Radl
- A. Zimmer
- B. Petit
- E. Gaud
- F. Polliart
- D. Colevret
- M. Schneider
- I. Guilbert-Brigger
- F. Yan
- F. Tranquart
- I. Pepić
- A. Hafner
- J. Lovrić
- J. Filipović-Grčić
- M. Metzler
- A. Hodzic
- P. Laggner
- N. A. Urbanetz
- J. Moor
- N. Heigl
- M. Burgstaller
- P. Kerschhaggl
- G. Hörl
- W. Tritthart
- F. Reiter
- M. Schlingmann
- M. Kriechbaum
- S. Fraser
- P. Laggner
- U. Roessl
- T. Grandjean
- A. Lench
- J. W. T. Yates
- M.J. Chappell
- C. J. O‘Donnell
- T. Mavromoustakos
- P. Zoumpoulakis
- M. Rappolt
- P. Laggner
- G. Pabst
- K. E. Pickl
- V. Adamek
- R. Gorges
- F. M. Sinner
- Š. Hadžidedić
- A. Uzunović
- S. Pilipović
- S. Kocova El-Arino
- S. Adam
- S. Radl
- G. Toschkoff
- C. Radeke
- M. Iannuccelli
- I. Kocic
- I. Homsek
- M. Dacevic
- S. Grbic
- H. Gruber-Woelfler
- P. W. Feenstra
- M.-G. Braunbruck
- R. Laskowski
- H. J. Bart
- T. Vovk
- B. Martinc
- I. Grabnar
- A. Corridoni
- C. Bacchiocchi
- A. Bonifacio
- M. Grassi
- E. Franceschinis
- S. Dall’Acqua
- M. Speh
- J. Plavec
- B. Lubura
- N. Gabra
- P. Starkl
- H. Viernstein
- F. M. Unger
- T. Luxbacher
- J. Petrović
- S. Ibrić
- G. Betz
- Z. Đurić
- S. Liebminger
- G. Schinagl
- L. Oberauner
- M. Aichner
- M. Cardinale
- J. Khinast
- G. Berg
- A. Glavač
- N. Nagelj Kovačič
- C. L. Levoguer
- L. Kidder
- K. Haber
- Z. Lavrič
- J. Pirnat
- J. Lužnik
- J. Seliger
- V. Žagar
- Z. Trontelj
- H. Santner
- L. Kis
- A. Szűts
- N. Otomo
- P. Szabó-Révész
- M. A. Deli
- M. T. Jaklič
- R. Jurečič
- M. I. Atari
- M. J. Chappell
- R. J. Errington
- P. J. Smith
- N. D. Evans
- G. Vuleta
- L. Baginski
- S. T. Buckley
- U. Bakowsky
- C. Ehrhardt
- R. Rošic
- S. Baumgartner
- S.Q. Wu
چکیده
Complexes of β-cylodextrin with five nucleotides of adenine (A), thymine (T) guanine (G), cytosine (C), and 5-methylcytosine have been investigated using Hatree-Fock (HF) and density functional theory (DFT) calculations of different quality. This work was inspired by recent technological advances made in singlemolecule sequencing of DNA. One molecule of single-stranded DNA can be sequenced by using nanopores made of α-hemolysin as the sequencing device. An exonuclease enzyme attached to the top of the pore cleaves bases from the DNA strand so they can traverse the pore one at a time. The different nucleotides then bind to cyclodextrin attached to the inside of the pore [1]. The different bases are discriminated by the change they induce in the amplitude of the current carried by aqueous ions passing through the pore. Several variants of this method are currently developed by different companies and will be marketed soon. We calculated low energy conformations of complexes of β-cyclodextrin with the five different nucleotides mentioned above, using different methods (HF, DFT). The interaction energy with β-cyclodextrin was estimated from the energy difference between a complex and the molecules it consists of. The presented results show, that it is possible to discriminate all five nucleotides very clearly. Because one can easily distinguish between cytosine and 5-methyl-cytosine, this method can be used to sequence methylated DNA directly in one step which might be an advantage compared to other similar sequencing methods.
منابع مشابه
Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.
Phosphopantetheine adenylyltransferase (PPAT) from Escherichia coli is an essential hexameric enzyme that catalyzes the penultimate step in coenzyme A (CoA) biosynthesis and is a target for antibacterial drug discovery. The enzyme utilizes Mg-ATP and phosphopantetheine (PhP) to generate dephospho-CoA (dPCoA) and pyrophosphate. When overexpressed in E. coli, PPAT copurifies with tightly bound Co...
متن کاملDiscovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with Streptococcus pneumoniae and Staphylococcus aureus ...
متن کاملThe crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity.
Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA). Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide-binding fold that is structurally similar to that in class I a...
متن کاملRole and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
Cancer cells exhibit altered metabolism including aerobic glycolysis that channels several glycolytic intermediates into de novo purine biosynthetic pathway. We discovered increased expression of phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) enzymes of de novo purine biosynthetic pathway in...
متن کاملA Nanocomposite Shield Constructed for Protection Against the Harmful Effects of Dental X-Rays
OBJECTIVES This study aimed to compare a number of new nano-composites capable of protecting the jaw from ionizing radiation. MATERIALS AND METHODS Four different types of nano-powders [Ti, Zr (IV) oxide, Ag and Co] were mixed in a polymer matrix to create nano-composites with doping values of 8% in weight. Small-angle X-ray scattering (SAXS) analysis was performed using a HECUSSAXS system wi...
متن کاملThe coenzyme a biosynthetic enzyme phosphopantetheine adenylyltransferase plays a crucial role in plant growth, salt/osmotic stress resistance, and seed lipid storage.
Coenzyme A (CoA) is an essential cofactor in the metabolism of both prokaryotic and eukaryotic organisms and a universal five-step pathway is utilized to synthesize CoA from pantothenate. Null mutations in two of the five steps of this pathway led to embryo lethality and therefore viable reduction-of-function mutations are required to further study its role in plant biology. In this article, we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 78 شماره
صفحات -
تاریخ انتشار 2010